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KMID : 0377619890540100705
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Korean Jungang Medical Journal
1989 Volume.54 No. 10 p.705 ~ p.710
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The Effect of Nifedipine of the Mized-Function Oxidase and Lipid Perozidation in the Spontaneous Hypertensive Fat Liver Microsomes
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Abstract
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The effect of intraperitonelly administered nifedipine, an antiphypertensive medication on the mixed-function oxidase system components, such as cytochrome P-450, cytochrome b5, NADPH- and NADH-cytochrome C reductause, p-nitroanisole-O-demethylase, and the formation of lipid peroxide and UDP-glucuronosyltransferase in the spontaneous hypertensive rat hepatic microsomes were investigated.
The result is as follows:
1. After 3-7 day of nifedipine injection bidaily, the contents of cytochrome P-450 and b5 were slightly increased and after 4 weeks of nifedipine injection bidaily, the contents of cytochrome P-450 and b5 were increased significantly.
2. After 2 and 4 weeks of nifedipine injection bidaily, the activities of NADPH- and NADH-cytochrome C reductase were increased significantly.
3. After 2 and 4 weeks nifedipine injection bidaily, the activities of monooxygenase, p-nitroanisole-O-demethylase were increased significantly.
4. The formation of lipid peroxide did not change for 4 weeks injection bidaily.
5. After 2 and 4 weeks of nifedipine injection bidnily, the activity of UDP-glucuronosyltransferase was increased markedly.
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